In addition, another mechanism that can affect the metastasis and migration of cancer cells under the influence of these drugs is the process of inhibiting nuclear factor kappa B (NF-κB) activity CBZ, also significantly inactivates the motility proteins, including myosin light chain 2 (MLC2), myosin phosphatase 1 target subunit 1 (MYPT1), and focal adhesion kinase (FAK), which are necessary for lymph endothelial cell migration and can reduce metastasis in a three-dimensional model of breast cancer cell culture (Teichmann et al., 2014). This evidence concerns the gene PPP1R12A and breast cancer.