For instance, NKCC1βKO mice gradually became overweight, hyperinsulinemic, hyperglycemic, hypertriglyceridemic, glucose intolerant and insulin resistant while developing mild non-alcoholic steatohepatitis and reduced β-cell mass and function, i.e., typical conditions found in MetS (Abdelgawad et al., 2022). The gene discussed is INS; the disease is metabolic syndrome.