ACE and hypertensive disorder: As our understanding of hypertension grew in the 1980s and 1990s, hydrochlorothiazide remained a key treatment for hypertension (Wilhelmsen et al., 1981; Hebert et al., 1993; Moser and Hebert, 1996; Savage et al., 1998), even as newer drugs with fewer, if any, metabolic issues (e.g., ACE inhibitors, calcium channel blockers and β-blockers) began to replace it (Officers et al., 2002; Grossman and Messerli, 2006).