CDKN1A and neoplasm: Of note, among the differentially expressed genes corresponding to an LOF in the p53Y217C mutant were Bbc3 (alias Puma), Cdkn1a (alias p21), and Zmat3 (Figure 4—figure supplement 3B), three p53 target genes known to play major roles in p53-mediated tumor suppression (Brennan et al., 2024).