TP53 and lymphoma: Furthermore, most Trp53-/- and Trp53YC/YC mice died from thymic lymphomas, but histological analysis of tumor organs revealed that the lymphomas in Trp53YC/YC males were more aggressive and invasive, with sites of metastases notably including the lungs, spleen, liver, or kidneys (Figure 4B and C, Figure 4—figure supplement 2).