Here, we observed increased chromosomal instability in Trp53YC/YC fibroblasts, increased NC-NF-κB and inflammation-related signaling in Trp53YC/YC thymocytes, and increased tumor metastasis in Trp53YC/YC mice compared to their Trp53-/- counterparts. Here, NFKB1 is linked to neoplasm.