These gene sets, differentially expressed between Trp53YC/YC and Trp53-/- cells, might contribute to accelerated tumorigenesis in Trp53YC/YC mice, given the reported impact of inflammation, metabolism changes, and epigenetic plasticity on cancer evolution (Feinberg et al., 2006; Greten and Grivennikov, 2019; Kroemer and Pouyssegur, 2008). This evidence concerns the gene TP53 and cancer.