Furthermore, most Trp53-/- and Trp53YC/YC mice died from thymic lymphomas, but histological analysis of tumor organs revealed that the lymphomas in Trp53YC/YC males were more aggressive and invasive, with sites of metastases notably including the lungs, spleen, liver, or kidneys (Figure 4B and C, Figure 4—figure supplement 2). The gene discussed is TP53; the disease is neoplasm.