Regarding the subtypes evaluated here, IgG3 represents the main subtype produced in response to infection by intracellular parasites (Tebo et al., 2001) and that IgG1 also plays an important role during T. gondii infection, with studies showing that IgG1 is induced during T. gondii infection by IFN-γ (Correa et al., 2007; Sana et al., 2022). This evidence concerns the gene IGHG3 and infection.