The ratios (relative to that of 0 nmol/L DCZ) of the frequency and amplitude of colonic tissues in Gi‐DREADD‐treated mice decreased after the administration of 10 nmol/L DCZ, when compared with the SS (frequency: 0.69 ± 0.01 vs. 0.95 ± 0.02, p < 0.01; amplitude: 0.65 ± 0.04 vs. 0.88 ± 0.04, p < 0.01), SD (frequency: 0.69 ± 0.01 vs. 0.99 ± 0.02, p < 0.01; amplitude: 0.65 ± 0.04 vs. 1.02 ± 0.04, p < 0.01) and AD groups (frequency: 0.69 ± 0.01 vs. 0.94 ± 0.05, p < 0.01; amplitude: 0.65 ± 0.04 vs. 1.00 ± 0.03, p < 0.01). The gene discussed is GNAI1; the disease is Alzheimer disease.