Acthar® Gel (repository corticotropin injection), which is a mixture of ACTH analogs (primarily N‐25 deamidated ACTH) and other peptides derived from porcine pituitary extract (Mallinckrodt Pharmaceuticals, 2021), may improve proteinuria and renal damage due to FSGS as shown in a rat PAN model of FSGS and patients with FSGS treated with Acthar. This evidence concerns the gene POMC and focal segmental glomerulosclerosis.