Oral administration of 2 or 17 mg/kg body weight of heat‐killed Enterococcus faecalis EF‐2001 to mice with colitis induced by rectal administration of dinitrobenzene sulfonic acid (DNBS) reduced the expression of several cytokines, including cyclooxygenase (COX)‐2, inducible nitric oxide synthase (iNOS), interferon (IFN)‐γ, interleukin (IL)‐1β, and IL‐6, in the inflamed colon and inhibited colonic tissue destruction compared to the DNBS‐only treatment group (Choi et al., 2019). Here, NOS2 is linked to colitis.