SPIRE1 and Parkinson disease: As depicted in Figure 5j, cells treated with NanoMassage showed a significant decrease in INF2, SPIRE1, and DRP1 levels compared to MPP+‐induced cells, indicating that even if they do not enter the neuronal cells, NanoMassage still regulate the inter‐organelle contact and mitigate mitochondrial fission through inhibiting actin filaments polymerization‐induced DRP1 oligomerization on mitochondria in PD model cells.