The polymerization and depolymerization of actin filaments have been shown to influence the clustering and functional activity of IP3R3, thereby regulating the dynamics of the IP3R3–GRP75–VDAC1 complex and MERCs functionality.[41] To explore the potential of NanoMassage in modulating MERCs, we assessed the expression levels of IP3R3, GRP75, and VDAC1 in an MPP+‐induced cell model of PD. Here, ITPR3 is linked to Parkinson disease.