PD is characterized by dopaminergic neuronal dysfunction in the SN region, as demonstrated by decreased levels of tyrosine hydroxylase (TH)—an enzyme involved in dopamine synthesis and postsynaptic density (PSD)—a protein associated with synaptic plasticity.[34] To evaluate the effects of NanoMassage on dopaminergic neuronal function in PD mice, TH immunohistochemistry was performed (Figure 2c). This evidence concerns the gene TH and Parkinson disease.