Taken together, pharmacologically or genetically inhibiting NLRP3 alleviated EtOH-induced cerebellar degeneration and behavioral deficits.<h4>Conclusion</h4>These findings indicated that DIPs might diminish EtOH-induced cerebellar degeneration and behavioral deficits through the NLRP3-ASC-caspase-1 signaling pathway, which provides a potential therapeutic target for the prevention and treatment of alcoholism and EtOH-induced cerebellar pathology. This evidence concerns the gene CASP1 and cerebellar degeneration.