ACSL4, a key enzyme in lipid peroxidation-induced ferroptosis,64 exacerbates LPS-induced mortality in a septic shock model when deficient.65 Conversely, SHP2 knockout mitigates LPS-induced ferroptosis by suppressing ACSL4 expression in acute lung injury.66 Vitamin D has also demonstrated a protective effect against ulcerative colitis by inhibiting ACSL4-mediated ferroptosis.67 The role of ACSL4 in septic injury-related ferroptosis is complex and warrants further investigation. This evidence concerns the gene PTPN11 and ulcerative colitis.