Although, we observed no differences in the abundance of L. murinus in blood and liver tissues between the CLP and CLP+L. murinus groups, the precise mechanism by which L. murinus influences the Hmgcs2 enzyme to modulate 3-HB production in the host remains unknown, as does the complex role of 3-HB in septic liver injury. This evidence concerns the gene HMGCS2 and digestive system neoplasm.