Consistent with these findings, immunohistochemical (IHC) analyses of human breast cancer biopsy samples revealed that ΔNp63α and FOXO3a protein levels were significantly decreased in invasive breast cancer specimens compared to primary breast cancer specimens, whereas ATF6 and GRP78 protein levels were markedly increased in invasive breast cancer specimens (Fig. 6B, C). The gene discussed is HSPA5; the disease is breast cancer.