Furthermore, we compared the mRNA expression levels of these genes across different AML FAB subtypes in the TCGA database and revealed that the expression levels of these genes are relatively higher in M6 and M7 (Fig. S5F–I) than in other subtypes, suggesting that RBM39 maintains the precise splicing of genes crucial for AMKL. This evidence concerns the gene RBM39 and acute myeloid leukemia.