TMEM160 promoted GC cells proliferation, invasion, migration, and chemoresistance by recruiting the E3 ligase TRIM37 to promote K48-linked ubiquitination and degradation of KEAP1, thereby activating the NRF2/GPX4/SLC7A11 axis and inhibiting ferroptosis (Fig. 8K). Here, NFE2L2 is linked to gastric cancer.