Given that the KEAP1/NRF2 antioxidant signaling pathway regulates ROS and iron metabolism-related genes and is a key negative regulator of ferroptosis in tumor cells [16, 18, 20], we hypothesized that TMEM160 regulates ferroptosis in GC cells via the KEAP1/NRF2 pathway. This evidence concerns the gene NFE2L2 and gastric cancer.