Additionally, mesothelioma is characterized by the frequent loss or mutation of tumor suppressor genes such as cyclin dependent kinase inhibitor 2 A (CDKN2A), BRCA1 associated protein 1 (BAP1), neurofibromin 2 (NF2), and cullin 1 (CUL1) [2]. The gene discussed is CUL1; the disease is mesothelioma.