CTLA4 and neoplasm: As described in Fig. 3A, the ultrasound images of representative tumors in the five groups during follow-up are shown in Fig. 3B, and the corresponding tumor growth curves of the five groups are displayed in Fig. 3C, showing that the triple combination treatment group (iRFA + LTX-315+anti-CTLA-4 antibody) had the smallest tumor volume compared with the other four groups (p < 0.001).