Presumably, the membranolytic effect of LTX-315 on plasma membrane can lead to an accumulation of DNA in the cytoplasm, which is perceived by the DNA sensors (cyclic guanosine phosphoadenosine synthase, cGAS) in cells, thereby activating the downstream protein of stimulator of interferon genes (STING), and causing secretion of type I interferon (IFN-I), resulting in an enhanced anti-tumor immunity [20–22]. The gene discussed is STING1; the disease is neoplasm.