Studies on older AD mouse models are not yet sufficient, but limited research has found that in older AD mouse models (15–18 months old), the levels of IL-6, IL-1β, and NF-κB are not significantly different from those in age-matched wild-type mice31.Taken together, these results revealed that older AD animals might represent better the inflammatory status of the symptomatic AD. The gene discussed is IL1B; the disease is Alzheimer disease.