,9,11 This can be observed upon BCL2 downregulation, upregulation of additional BH3-family anti-apoptotic proteins such as BCL-XL, BCL-W, and MCL1, and even monocytic-like AML populations were observed to be inherently resistant and positively selected upon treatment with venetoclax.2 This evidence concerns the gene MCL1 and acute myeloid leukemia.