Skeletalmuscle is among the principal sinks for insulin-mediated whole-bodyglucose disposal, but this action becomes impaired under hyperlipidemicconditions due to the development of insulin resistancea conditionthat is tightly associated with the accumulation of intramyocellularlipid., The resulting chronic hyperglycemia, inturn, promotes hepatic de novo lipogenesis. With a doubling of total FA levels in the skeletalmuscle tissue samples, our HF mouse model recapitulated this importantaspect of metabolic syndrome. The gene discussed is INS; the disease is Hyperglycemia.