Documented ovarian failure, including basal FSH >10 IU/L or no antral follicles on ultrasound; PCOS; hydrosalpinx; adenomyosis on the laparoscopy or laparotomy; hormone treatment within 3 month; mild or peritoneal endometriosis; moderate to severe intrauterine adhesion. The gene discussed is BRD2; the disease is polycystic ovary syndrome.