Documented ovarian failure, including basal FSH >10 IU/L or no antral follicles on ultrasound; PCOS; hydrosalpinx; adenomyosis on the laparoscopy or laparotomy; hormone treatment within 3 month; mild or peritoneal endometriosis; moderate to severe intrauterine adhesion. This evidence concerns the gene BRD2 and ovarian dysfunction.