E2F1 and colorectal cancer: For example, Jing et al. showed that Non-SMC Condensin II Complex Subunit D3 (NCAPD3) bound to E2F1 to increase E2F1-mediated transcription of Pyruvate dehydrogenase kinase (PDK) 1 and PDK3 genes, then suppressed the pyruvate dehydrogenase activity and tricarboxylic acid (TCA) cycle, thereby promoting colorectal cancer progression by enhancing Warburg effect [13].