The tumor sphere formation assay showed that EXOSC10 deletion declined the sphere formation rate in Huh-7 and Hep3B cells (Fig. 4G), as well as impaired the expression of OCT4 and CD44 proteins (Fig. 4H, I), indicating the inhibition of cancer cell stemness after EXOSC10 knockdown. Here, POU5F1 is linked to cancer.