HIF1A and metabolic dysfunction-associated steatotic liver disease: Cui et al. research has shown that the gas transport agent CO released by tyrene maleic acid copolymer encapsulating CO-releasing molecule (SMA/CORM2) led to the inhibition of classical activated macrophages (M1) polarization in macrophages and the activation of NOD-like receptor protein 3 (NLRP3) inflammasome, modulated MASLD induced by HF-MCD though the significant inhibition of HIF-1α [47].