ACOT2 and Hepatic fibrosis: Additionally, PPARα effectively alleviated liver inflammation and inhibited liver fibrosis by promoting fatty acid oxidation (CYP4A10, CYP4A14, ACOT2(acyl-CoA thioesterase 2) and CROT (carnitine O-Octanoyltransferase) and suppressing lipogenesis, which was crucial in slowing the progression of hepatocellular carcinoma (HCC) [73].