According to another study, Jiuzhuan Huangjing Pills (JHP) extract normalized mitochondrial metabolism by restoring ATPase activity, and mitochondrial complex function, additionally, mitigated hepatic lipid metabolism and oxidative stress by upregulating the expression of key genes involved in fatty acid metabolism, such as PGC-1, acyl-CoA dehydrogenase long chain (ACADL) and PPAR-α in HFD-induced MASLD mice model [19]. Here, PPARGC1A is linked to metabolic dysfunction-associated steatotic liver disease.