When TREM2 were overexpressed, the macrophage pyroptosis can be inhibit through PI3K/AKT pathway and the macrophage can be reprogrammed by up-regulating transforming growth factor (TGF)-β1 (a main inducer of macrophage M2 polarization) to anti-inflammatory phenotype, thereby treating MASLD [43]. The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatotic liver disease.