Choi et al. demonstrated that netrin-1 expressed macrophages could upregulate PPARγ expression by activating the unc-5 netrin receptor B (UNC5b) receptor to promoted autophagy through increasing LC3 conversion, p62 degradation, and autophagosome formation, suppressing hepatic steatosis in HFD-induced MASLD mice model [21]. Here, PPARG is linked to metabolic dysfunction-associated steatotic liver disease.