ACLY and metabolic dysfunction-associated steatotic liver disease: HFD caused the disorder of PPARγ-related fatty acid synthesis and PPARα-dependent fatty acid oxidation in MASLD model, while, Taohe Chengqi Decoction (THCQ) enhanced branched chain amino acids (BCAA) catabolism to reduce phosphorylation of ATP citrate lyase (ACLY) to inhibit lipid synthesis, promoted lipid oxidation, and significantly alleviated MASLD [23].