PDCD1 and metabolic dysfunction-associated steatotic liver disease: While Omega-3 fatty acids ameliorated MASLD by resolving inflammation and fibrosis through metabolic reprogramming of immune cells, the persistent dysregulation of immune checkpoints such as programmed cell death protein 1 (PD-1) in exhausted T cells suggested a potential synergistic therapeutic strategy to together target metabolic dysfunction and immune exhaustion in advanced MASLD.