In HFD-induced MASLD mice model, matrin-3 deficiency led to a reduction in the expression of CAR in the liver, resulting in carboxylesterase 2a (Ces2a) decrease to facilitate lipid accumulation meanwhile I interleukin 1 receptor (IL-1R1), signal transducer and activator of transcription 3 (STAT3) phosphorylation increase to facilitate phase response [15]. The gene discussed is STAT3; the disease is metabolic dysfunction-associated steatotic liver disease.