Danthron upregulated adiponectin receptor 2 (AdipoR2) expression to, on the one hand, activate the AMPKα pathway and, on the other hand, enhance the nuclear translocation of the PPARα/retinoid X receptor (RXRα) heterodimer and bind with the AdipoR2 promoter, thereby promoting fatty acid oxidation, mitochondrial biogenesis, and energy expenditure in HFD-induced MASLD mice model [26]. This evidence concerns the gene ADIPOR2 and metabolic dysfunction-associated steatotic liver disease.