GLS2 and metabolic dysfunction-associated steatotic liver disease: According to another study, in HFD-induced MASLD mice model, the downregulation of methyltransferase-like 14 (METTL14) decreased glutaminase 2 (GLS2) protein levels by reducing N6-methyladenosine (m6A) modification of GLS2 mRNA, which exacerbated oxidative stress in the liver.