Ginsenoside F2 (GF2) also showed beneficial effects in inhibiting macrophages accumulation in HFD-induced MASLD mice model, inhibited LXR activity and decreased F4/80 hepatic macrophage infiltration and inflammatory cytokines (IL-1β, TNF and IL-6) expression, thereby exerting anti-steatosis and anti-inflammatory effects [33]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatotic liver disease.