Concretely, Sirt1 promoted mitochondrial biogenesis and function by deacetylating peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), enhanced lipophagy and reduced lipid accumulation through the deacetylation of forkhead box O3a (FoxO3a) in HFD-induced MASLD mice model [18]. Here, SIRT1 is linked to metabolic dysfunction-associated steatotic liver disease.