SPP1 and neoplasm: Furthermore, SPP1, S100A9, and S100A11 genes exhibited strong positive associations with the majority of tumor-infiltrating immune cells, while PAFAH1B3, MARCKSL1, KIF2C, CYP2C9, CFHR4, CDO1, C6, and SLC2A2 genes exhibited significant negative associations with most tumor-infiltrating immune cells (Figure S6G and Figure S7).