PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Genetic variants in genes such as transmembrane six superfamily member 2 (TM6SF2) [34], glucokinase regulatory protein (GCKR) [35], and patatin-like phospholipase domain-containing-3 (PNPLA3) [36] are found to associate with NAFLD and NASH, with PNPLA3 classified as one of the most common genetic variations.Patients who have the PNPLA3 genetic polymorphism produce a truncated lipase enzyme which impedes triglyceride breakdown and subsequently reduces liver triglyceride (TG) secretion in the form of very-low-density lipoproteins (VLDL).