To gain insight into the alterations induced by RRAS2 overexpression in breast tumors, we performed RNAseq analysis on thirteen independent tumors that emerged in eight Rosa26-RRAS2fl/fl mice (two MMTV-Cre+, four Sox2-Cre+, two Wap-Cre+; see Extended Data Table 1) that had been through one or more pregnancies, and nine samples of normal mammary gland tissue (two non-transgenic nulliparous females, three non-transgenic breeders, two Cre-Rosa26-RRAS2fl/fl nulliparous females, and two Cre-Rosa26-RRAS2fl/fl pregnant females) [35]. Here, SOX2 is linked to breast neoplasm.