In contrast, the Tcf7l2 cKO mice harbored a substantial concentration of bacterial strains, including Enterococcus and Escherichia-Shigella, which are commonly found in patients with inflammatory bowel disease (IBD) [59] (Fig. 1D and Supplementary material 8: Supplementary Figure S2B). The gene discussed is TCF7L2; the disease is inflammatory bowel disease.