The observed process of a (stochastic) reversal of the phenotype of Defa6-tdTom cells from a secretory type (see below), or possibly an earlier activation of Defa6-iCre expression in a group of so-called tumor stem cells, is consistent with the fact that the number and size of glandular structures in Apc+/Min mouse tumors are quite variable, but always correlate with the size (age) of the tumor. The gene discussed is DEFA6; the disease is neoplasm.