ZNRF3 and intestinal neoplasm: This assumption was confirmed by the observation that the majority of cells in the clusters examined expressed the Wnt signaling target gene Axin2, Rnf43, Sp5, Wnt inhibitory factor 1 (Wif1), and zinc and ring finger 3 (Znrf3), which had previously been identified as a target gene in intestinal tumors [101] (Fig. 6DE).