CEBPA and acute myeloid leukemia: HPC-7 cells recapitulate the transcriptomic and epigenetic landscape of mouse HSCs46,47; do not harbor typical AML mutations; and exhibit very low levels of endogenous CEBPA (Supplementary Fig. 1a), making them an ideal model to delineate the transcriptomic effects of p30 and p42 in HSCs.