Since the AP-1 binding motif was significantly associated to enhancers downregulated in p30 cells, we examined expression of the main four AP-1 subfamilies in p30-expressing HPC-7 cells, macrophages, hematopoietic progenitors and CEBPANT/bi-mutant AML, and we observed that the FOS subfamily was consistently the most downregulated by p30 (Supplementary Fig. 6a). The gene discussed is FOS; the disease is acute myeloid leukemia.