At KEGG level 3, K. quasipneumoniae abundance was linked to key pathways involved in BLM-induced lung fibrosis, such as the AMPK, HIF-1, VEGF, PI3K-Akt, and NF-kappa B signaling pathways, as well as bacterial invasion of epithelial cells, ECM-receptor interaction, and IL-17 signaling (Fig. 4B and Supplementary Fig. S1). Here, AKT1 is linked to pulmonary fibrosis.