CASP8 and non-small cell lung carcinoma: We found that PBMCs treated with MET alone were not able to induce in vitro cell death in NSCLC cell lines, whereas the combination of MET with anti-PD-1/PD-L1 activated immune cells-mediated cytotoxicity through Caspase-8 increase in H1299 and strong Lamin A/C upregulation (Fig. 4B).