Moreover, UVB irradiation at a dose of 500 mJ on the dorsal skin of RIPK3 knockout (RIPK3-KO) mice demonstrated a significant mitigation of UVB-induced skin damage, as evidenced by decreased scores of skin damage (Table 1, Fig. 6A), as well as ameliorated necrosis and apoptosis of keratinocytes in the mouse epidermis (Fig. 6B, C). The gene discussed is RIPK3; the disease is neoplasm.