These ISGs are known to positively modulate the expression of phosphorylated signal transducer and activator of transcription 1/IFN-β/retinoic acid-inducible gene G to inhibit viral infection, thereby inhibiting viral infection and inducing pro-inflammatory reactions (Bréhin et al., 2009; Schoggins et al., 2011; Zhu et al., 2014). The gene discussed is STAT1; the disease is viral infectious disease.