SLC19A3 and Thiamine deficiency: These two transporters are widely expressed in human tissues, and the intracellular thiamine deficiency caused by THTR-1 mutation can be compensated by THTR-2 and passive transport in most tissues.13, 14 However, THTR-1 is the only known transporter in bone marrow cells, pancreatic beta cells, and some cochlear cells, which is the etiology of the clinical typical triad of TRMA syndrome.15