Interestingly, in lung cancer cells A549 (Supplementary Fig. 2A), HEK293T (Supplementary Fig. 2B), neuroblastomas cells SK-N-BE(2) (Supplementary Fig. 2C) and breast cancer cell line MCF7 (Supplementary Fig. 2D) AGO2 and p53 are ubiquitously expressed but interact exclusively within the nucleus (Supplementary Fig. 2A–D). The gene discussed is TP53; the disease is lung cancer.