AGO2 and lung cancer: Interestingly, in lung cancer cells A549 (Supplementary Fig. 2A), HEK293T (Supplementary Fig. 2B), neuroblastomas cells SK-N-BE(2) (Supplementary Fig. 2C) and breast cancer cell line MCF7 (Supplementary Fig. 2D) AGO2 and p53 are ubiquitously expressed but interact exclusively within the nucleus (Supplementary Fig. 2A–D).