We found that voxel-wise intensity of IgG staining in periventricular NAWM and WMH of individuals with hypertension and control individuals positively correlated to GLUT1 staining intensity (ρ = 0.238, p < 0.001) and area of perivascular MMP9 (ρ = 0.290, p < 0.001). Here, MMP9 is linked to hypertensive disorder.