We found that voxel-wise area of perivascular MMP9 in periventricular NAWM and WMH of individuals with hypertension and control individuals positively correlated with larger vessel walls (ρ = 0.323, p < 0.001) and Masson’s staining intensity (ρ = 0.242, p < 0.001). This evidence concerns the gene MMP9 and hypertensive disorder.