It is important to note that clinical trials on MMPs inhibition highlight short-term treatment as a more promising option, since medium and long-term trials have yielded mixed results (reviewed by36) Drugs like Miconazole,37 able to inhibit MMP9 downstream effects, e.g. MMP9-mediated vessel rupture, may prove beneficial in successfully reducing the progression of WMH, and ultimately dementia. Here, MMP9 is linked to dementia.