We found that voxel-wise area of IgG positively correlated to αSMA intensity (ρ = 0.312, p < 0.001) and intensity of perivascular MMP9 in periventricular NAWM and WMH of individuals with hypertension and control individuals (ρ = 0.370, p < 0.001). The gene discussed is ACTA1; the disease is Hypertension.