Voxel-wise MRI signal throughout periventricular WMH and NAWM in individuals with hypertension and control individuals positively correlated with larger vessel walls (ρ = 0.405, p < 0.001) and Masson’s staining intensity (ρ = 0.403, p < 0.001), and GLUT1 intensity per microvasculature (ρ = 0.457, p < 0.001). Here, SLC2A1 is linked to Hypertension.