CoDE-HF with BNP had an AUC of 0.914 (0.906–0.921) and a Brier score of 0.110 in patients without prior heart failure and an AUC of 0.848 (0.831–0.864) and Brier score of 0.123 in those with prior heart failure (Figure 3 and Supplementary material online, Figure S4). This evidence concerns the gene NPPB and heart failure.