For BNP, a CoDE-HF score of 5.4 achieved an NPV of 98.5% (97.1–99.3%) and a sensitivity of 98.9% (98.0–99.3%), whilst a score of 58.0 achieved a PPV of 78.6% (70.4–85.0%) and a specificity of 90.2% (86.8–92.8%) in those without prior heart failure (Table 2 and Supplementary material online, Table S5). The gene discussed is NPPB; the disease is hydrops fetalis.