CoDE-HF was well calibrated with excellent discrimination in those without prior acute heart failure for both BNP and MR-proANP [area under the curve of 0.914 (0.906–0.921) and 0.929 (0.919–0.939), and Brier scores of 0.110 and 0.094, respectively]. The gene discussed is NPPB; the disease is hydrops fetalis.