CoDE-HF with MR-proANP achieved an AUC 0.929 (0.919–0.939) and Brier score of 0.094 in patients without prior heart failure, and AUC 0.857 (0.831–0.882) and Brier score of 0.122 in patients with prior heart failure (see Supplementary material online, Figures S5–S6). This evidence concerns the gene NPPA and heart failure.