For MR-proANP, a CoDE-HF score of 8.1 achieved an NPV of 98.5% (97.7–99.0%) and sensitivity of 97.3% (95.5–98.4%), whilst a score of 46.0 achieved a PPV of 75.1% (70.9–78.9%) and a specificity of 90.4% (86.1–93.5%) in those without prior heart failure (Table 2 and Supplementary material online, Table S6). Here, NPPA is linked to heart failure.