Its correlation with age,40, 69, 71, 74, 77 basal forebrain volume,41 longitudinal dementia status,69 amyloid pathology,57, 59 hippocampal atrophy,47, 57 plasma p‐tau217 and p‐tau181,56 CSF NfL,39 and cognitive domains such as verbal fluency,43 visuospatial ability,60 and episodic memory60 highlights its relevance in tracking neurodegeneration in DS individuals. This evidence concerns the gene NEFL and dementia.