Furthermore, there have been reports of significant differences in the levels of plasma biomarkers (IL‐6, IL‐10, TGF‐β1, etc.)71, 85, 86, 87, 88, 89, 92 and serum CRP,97 beta‐synuclein,84 BDNF,91 APL1β25,98 APL1β27,98 APL1β28,98 MHPG,98 sTREM2,93, 95 IL‐694, 95 of individuals with DS compared to euploid controls. The gene discussed is IL10; the disease is Dravet syndrome.