Further analysis of the apolipoprotein E (APOE) ε4 genotype in the DS population revealed that carriers of the APOE ε4 allele had lower CSF Aβ1‐42 to Aβ1‐40 ratios before the age of 40, and showed earlier increases in amyloid PET uptake and plasma p‐tau181 levels, along with earlier cortical metabolic decline and hippocampal volume loss.42 The gene discussed is APOE; the disease is Dravet syndrome.