For example, mediators (HMFBI, MMP‐3, and tPA), microglial (sTREM2), as well as cytokines (IL‐6, IL‐10, TGF‐β1, IL‐2, IL‐1ra, GM‐CSF, Epo, IL‐1 β), showed significant differences in plasma between DS individuals and euploid controls, though some biomarkers (IL‐6, IL‐10, TNFα, TGF‐β1, IL‐2, IL‐1α, IL‐12, MCP‐1) in serum did not produce significant results or some like IL‐6 exhibited varying outcomes across studies.71, 85, 86, 87, 88, 90, 91, 92, 93, 94, 95. This evidence concerns the gene IL6 and Dravet syndrome.