In our meta‐analysis (Table 3), for DS versus euploid controls, based on 10 studies involving 1741 DS individuals and 896 euploid controls, the SMD was 0.49 (95% CI [0.23, 0.75], z = 3.64, p = 0.0003), indicating significantly higher plasma NfL levels in the DS group. This evidence concerns the gene NEFL and Dravet syndrome.