Furthermore, there have been reports of significant differences in the levels of plasma biomarkers (IL‐6, IL‐10, TGF‐β1, etc.)71, 85, 86, 87, 88, 89, 92 and serum CRP,97 beta‐synuclein,84 BDNF,91 APL1β25,98 APL1β27,98 APL1β28,98 MHPG,98 sTREM2,93, 95 IL‐694, 95 of individuals with DS compared to euploid controls. This evidence concerns the gene IL6 and Dravet syndrome.