Examples include medulloblastoma, where genomic rearrangements lead to the activation of growth factor independence 1 (GFI1) family oncogenes,52 neuroblastoma, where neo‐TADs result in MYC activation,95 leukemia involving the activation of EVI1/MECOM,94, 97 and salivary gland tumors, where these changes drive NR4A3 expression.98 Here, MECOM is linked to neuroblastoma.