APOE and Alzheimer disease: In both cohorts, MMSE at baseline was higher in AD A+T− compared to AD A+T+ (Amsterdam: β = −0.86, p < 0.001; ADNI: β = −1.03, p < 0.001), and, AD A+T− tended to be more often APOE ε4 carrier compared to AD A+T+ in ADNI, although at trend level (ADNI: p = 0.05).