In individuals with knee osteoarthritis, supplementation with creatine (20 g/d for one week followed by 5g/d for 11 weeks) does not affect C-reactive protein, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 or s100 A8/A9 concentrations in the systemic circulation [29]. Here, TNF is linked to osteoarthritis, knee.