Additionally, visceral obesity [24], T2DM [1], dyslipidemia [25], and arterial hypertension [26] are well-established risk factors promoting MASLD onset and progression, with genetic predispositions, such as PNPLA3 and TM6SF2 [27] polymorphisms, further increasing susceptibility. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.