The role of SIRTs in atherosclerosis is relatively clear, with main effects in regulating LDL cholesterol levels, macrophages, foam cells, and endothelial function through various factors and signaling pathways; SIRT1, SIRT3, and SIRT6 are the sirtuins involved in protecting against atherosclerosis and cardiac hypertrophy [99,100,101]. The gene discussed is SIRT1; the disease is atherosclerosis.