TGFB1 and renal fibrosis: According to previous studies, SIRT1 and SIRT3 (both decreased in TGF-β-induced EndMT) seem to be TGF-β inhibiting factors [111,112], so their upregulation could be a chance to attenuate both cardiac and renal fibrosis, thus mitigating cardio-renal syndromes, in which fibrosis plays an important role [113].