In vitro studies showed that resveratrol decreased IR, intracellular Aβ peptides, and reduced tau phosphorylation by inactivating GSK3 to defend against aging and AD processes [110], through the silent information regulator 1 (SIRT1), AMP-activated protein kinase (AMPK), NLRP3 inflammasome, and NF-kB pathways [99,101]. Here, SIRT1 is linked to Alzheimer disease.