Hu et al. indicated that quercetin supplementation in diabetic mice increased the protein expression of SIRT1 and decreased the expression of inflammation-related proteins, including NLRP3, and cleaved caspase-1 and pro-inflammatory cytokines such as IL-1β and IL-18, suggesting that quercetin may be important in the treatment of AD [157]. Here, SIRT1 is linked to Alzheimer disease.