BACE1 and Alzheimer disease: In the 3xTg-AD mouse model and human neuronal-glial cells, neuroprotectin D1 stereoselective mediator derived from DHA suppressed the Aβ42 peptide by downregulating BACE1 and activating α-secretase and upregulating sAPPα, thus shifting the cleavage of βAPP from the amyloidogenic to the non-amyloidogenic pathway [179].