We have previously reported that Greek Orthodox fasting, due to the unique combination of vegetarian and iso- or, in some cases, hypo-caloric patterns and extended daily time-frames of fasting (16–18 h daily), results in significant benefits in adipokine profiles, including increased adiponectin and omentin and reduced visfatin and nesfatin concentrations, compared to standard dietary patterns suggested for dyslipidemia [16,17,18,19,25,31,32,33]. This evidence concerns the gene NUCB2 and metabolic syndrome.