PGF and endothelial dysfunction: Endothelial dysfunction results from an imbalance in angiogenic and anti-angiogenic factors, particularly the overexpression of soluble fms-like tyrosine kinase-1 (sFlt-1), which antagonizes vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), impairing angiogenesis and increasing vascular resistance [2].