However, in obesity, the impaired PI3K/Akt signaling leads to unphosphorylated FOXO1, which remains localized in the nucleus, promoting the transcription of genes involved in glucose generation (e.g., G6Pase and PEPCK) and lipid storage, leading to hyperglycemia and adiposity [51]. The gene discussed is FOXO1; the disease is obesity due to melanocortin 4 receptor deficiency.