In addition, molecules including Hypoxia-Inducible Factor (HIF), Inducible Nitric Oxide Synthase (iNOS), COX, Matrix Metalloproteinases (MMPs), and TGF-β, along with the activation of signaling pathways like NF-κB and Janus Kinase/signal Transducers and Activators of Transcription (JAK/STAT) [97], collectively promote tumor initiation, transformation, progression, and metastasis [98,99,100]. This evidence concerns the gene NOS2 and neoplasm.