SIRT5 knockout mice also exhibited less browning capacity in subcutaneous white adipose tissue and showed apparent cold intolerance [18] and may be associated with protein high-succinylation patterns, including glutamate dehydrogenase (GDH), alcohol dehydrogenase A (ADHA), and uncoupling protein 1 (UCP1), leading to impaired metabolic functions, manifested as glucose intolerance, defective cold adaptation, and mitochondrial dysfunction [19]. Here, UCP1 is linked to Glucose intolerance.