Studies in obesity-induced diabetic mice support the role of curcumin (the active ingredient in turmeric) in modulating nitrergic-mediated gastric motility and gastric emptying via normalizing inflammation and oxidative stress through activation of nuclear factor erythroid 2-related factor 2, which increases neuronal NOS gene expression and function [132]. The gene discussed is NOS1; the disease is obesity due to melanocortin 4 receptor deficiency.