Studies in obesity-induced diabetic mice support the role of curcumin (the active ingredient in turmeric) in modulating nitrergic-mediated gastric motility and gastric emptying via normalizing inflammation and oxidative stress through activation of nuclear factor erythroid 2-related factor 2, which increases neuronal NOS gene expression and function [132]. This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.