TLR9 and asthma: Our findings open avenues for several future research directions, e.g., large-scale genetic association studies conducting multi-center genome-wide association studies (GWAS), longitudinal cohort studies following asthmatic patients over time to assess how TLR9 and TLR10 polymorphisms influence disease progression, exacerbations, and long-term cardiac and pulmonary outcomes, and therapeutic targeting of the TLR pathways could improve asthma control and reduce associated cardiac dysfunction.