Imaging features, together with biochemical evaluation (levels of serum tumor markers like alpha-fetoprotein (AFP), lactate dehydrogenase (LDH), beta subunit of human chorionic gonadotropin (β-hCG), cancer antigen 125 (CA-125), inhibin A and B), are crucial in the assessment of the risk of malignancy, as the management of benign and malignant lesions is essentially different [9]. The gene discussed is MUC16; the disease is neoplasm.