SMAD3 and connective tissue disorder: The authors identified several CRF and CCT loci harbored within 1 Mb of mendelian genes associated with rare corneal or connective tissue diseases. These included FECD7, TCF4, SLC4A11, UBIAD1, MPV17, ZNF513, COL5A1, ZNF469, COL8A2, AGBL1, SMAD3, DCN, KERA, and TGFB2.