The authors identified several CRF and CCT loci harbored within 1 Mb of mendelian genes associated with rare corneal or connective tissue diseases. These included FECD7, TCF4, SLC4A11, UBIAD1, MPV17, ZNF513, COL5A1, ZNF469, COL8A2, AGBL1, SMAD3, DCN, KERA, and TGFB2. The gene discussed is DCN; the disease is connective tissue disorder.